Antibody Testing | HLA Antibody Testing | Kashi Clinical Laboratories

KIR Genotyping

Engraftment | Kashi Clinical Laboratories

Killer cell immunoglobulin-like receptors (KIRs) are members of a group of regulatory molecules found on subsets of lymphoid cells. They were first identified by their ability to impart some specificity on natural killer (NK) cytolysis.

The KIR locus, containing a family of polymorphic and highly homologous genes, maps to chromosome 19q13.4 within the 1 Mb leukocyte receptor complex. The discovery of KIR has revealed an additional function of the human leukocyte antigen (HLA) class I molecules. Through their interaction with KIR isotypes that inhibit natural killer (NK) cell activity, certain HLA class I molecules are now known to protect healthy cells from spontaneous destruction by NK-cell-mediated cytolysis. Other KIR isotypes stimulate the activity of NK cells. The degree of HLA/KIR compatibility may determine the success rate of haematopoietic cell replacement therapy for certain leukemia’s.

KIR typing is used for selecting the best hematopoietic stem cell transplant donor for recipients with multiple donors who are potential HLA-matched or otherwise equivalent. The identification of KIR genotypes can allow for an improved donor selection that may lead to enhanced engraftment and reduced graft-versus-host disease.

Environmental Testing | Kashi Clinical Laboratories

Kashi Laboratories works directly with providers to make ordering tests as easy as possible.

To request environmental testing at Kashi Labs, please visit the Order Now page and contact us to get started.

Kashi Laboratories works directly with providers to make ordering tests as easy as possible.

To request toxicology testing at Kashi Labs, please visit the Order Now page and contact us to get started.

What can we help you find?

Place a one-time order for genetic testing at order.kashilab.com.

If you are an existing provider, please sign in to place an order through the online portal. If you are new to Kashi and would like to create an account, please contact us.

Kashi Laboratories works directly with providers to make ordering tests as easy as possible.

Place a one-time order by contacting us through the form at the link below, or get started by logging in to your online portal.

Ordering a kit is easy! To purchase a Private Testing Kit, please visit the link below and follow the steps provided.

BoneMarrowTest.com is a service of Kashi Clinical Laboratories. For more information regarding Private HLA Testing or to order a test kit, please visit BoneMarrowTest.com.

*By clicking the link above you will be redirected to BoneMarrowTest.com.

Antibody Testing | HLA Antibody Testing | Kashi Clinical Laboratories

Kashi Labs has partnered with ThermoFisher to bring MMDx to our patients and providers.

Find more information regarding MMDx for Molecular Biopsy Assessment, sample reports, and free specimen collection kit orders.

*By clicking the link above you will be redirected to the ThermoFisher website.