MTHFR — Methyltetrahydrofolate | Kashi Clinical Laboratories

Genetic Testing

Every day, research leads to new genetic tests for the diagnosis of various diseases and health conditions.

Genetic testing can be used to determine susceptibility to, and aid in diagnosis of, disease in patients of all ages.

A test for genes can identify changes in chromosomes, genes, or proteins. Such information can help your healthcare provider confirm or eliminate a suspected genetic condition, or help them to determine your chance of developing or passing on a genetic disorder. Currently, more than 1,000 genetic tests exist and the field continues to grow.

  • Information to support a diagnosis if someone has symptoms of a disease.
  • Evidence a person is a carrier for a marker associated with a genetic disease. 
  • Guidelines on lifestyle choices in the short and long term.
  • Indications as to whether a person may have an increased risk of developing disease before symptoms start.
  • Support for the type of medication that is most likely to be effective for each individual – known as pharmacogenetics.

There are numerous genes that are found all throughout the genome where, in many cases, there is no physiological consequence for possessing one allele versus another. Consequently, before inclusion in the panel, each gene was carefully researched by Kashi’s PhD level scientists to assure that only the most informative genetic markers that have a well-established impact on health would be included in the test. Every gene in the genetic panel has been carefully selected based on the following criteria:

  1. Several clinical trials published in peer-reviewed journals have reported a connection between the gene and the condition.
  2. The gene must have a well established association with a particular disease or health condition.
  3. The gene impacts a significant portion of the general population.

Example Dr. Getchuwell’s patient has been feeling uneasy in her abdominal area, noticing excess gas and bloating, along with weight loss. The patient thinks her stomach trouble could be diet-related. Dr. Getchuwell discovers the patient’s mother has Celiac Disease and feels healthier on a gluten-free diet. Given her family’s history, Dr. Getchuwell suspects this patient may be at risk for Celiac Disease, but wants to be sure. By ordering a non-invasive buccal swab genetic test from Kashi Health, the doctor can determine the patient’s level of risk. If Celiac Disease is confirmed, Dr. Getchuwell can also prevent nutrient deficiencies causing anemia, fatigue, and skin and bone problems, and suggest additional lifestyle changes.

The foundation of genetic material in all living organisms is found within a molecule called deoxyribonucleic acid, or DNA. Often referred to as the genetic code, DNA is comprised of four bases: adenine (A), cytosine (C), guanine (G), and thymine (T). Collectively, the content of the genetic code within each organism is referred to as the genome. Within the human genome over 99% of this code is identical among individuals. It is the alterations in the remaining <1% that account for all of the diversity in characteristics like height, eye color, memory or intelligence to name a few.

The basic functional unit of inherited traits is the gene. Made up of DNA, genes vary in size from several hundred to millions of bases. The human genome contains roughly 20,000 genes, each containing the information required to produce a specific protein. Each individual inherits two copies of every gene, one from their mother and the other from their father. When there are alterations of the DNA sequence of a particular gene, the different versions of the gene are referred to as alleles. Personal characteristics, such as hair and eye color, are determined by which specific allele they inherit.

Proteins, of varying size, are coded by our genes and play many critical roles. Found all throughout the tissues and organ systems in the body, they are integral to maintaining physiological structure and function. Proteins differ dramatically in size and conformation, yet they are all made up of the same 20 amino acids. These amino acids are linked together in chains that are ultimately folded together to form the 3-D shape of the protein. Consequently, the order and number of amino acids in these chains determines the form and function of each protein.

Enzymes are a very specialized type of protein. They facilitate almost all of the thousands of chemical reactions that take place in cells. Often if there is a problem with the structure of an enzyme, the result is some form of disease.

Kashi Health focuses on molecular genetic tests to study single genes, or short lengths of DNA, to identify variations or mutations that lead to disorders and disease.

To better understand genetic testing, it is helpful to understand the basics of how human genetic material is organized.

Is genetic testing right for you?

For many people, it is essential to know whether a disease can be prevented if a gene alteration is discovered. If you suspect you may be at an increased risk for a disease, talk to your family doctor or we invite you to select from a trusted Kashi Health Provider.

The information about your symptoms and background can help you and your doctor decide whether genetic testing is worth pursuing. If a genetic risk is identified, you might be able to change your lifestyle to prevent a disease from developing. The information can also help your doctor provide better treatment, as well as a follow-up plan tailored to your individual needs. Kashi has developed a series of genetic test panels that have significance to some of the most pressing health issues of our time including: obesity and weight management, cardiac health, mental and behavioral health, nutritional status and pain medication management. All genetic markers selected by the lab for inclusion in the DNA test panels meet strict acceptance criteria based on extensive literature searches and multiple peer-reviewed scientific studies. All reports are structured to be informative, practical and patient friendly.

It can be challenging to keep up to date on new research  – Kashi does that for you.

Kashi Health’s genetic testing services could lead to a healthier you.

Order SNP Genotyping and Condition-Related HLA Panels.

Environmental Testing | Kashi Clinical Laboratories

Kashi Laboratories works directly with providers to make ordering tests as easy as possible.

To request environmental testing at Kashi Labs, please visit the Order Now page and contact us to get started.

Kashi Laboratories works directly with providers to make ordering tests as easy as possible.

To request toxicology testing at Kashi Labs, please visit the Order Now page and contact us to get started.

What can we help you find?

Place a one-time order for genetic testing at order.kashilab.com.

If you are an existing provider, please sign in to place an order through the online portal. If you are new to Kashi and would like to create an account, please contact us.

Kashi Laboratories works directly with providers to make ordering tests as easy as possible.

Place a one-time order by contacting us through the form at the link below, or get started by logging in to your online portal.

Ordering a kit is easy! To purchase a Private Testing Kit, please visit the link below and follow the steps provided.

BoneMarrowTest.com is a service of Kashi Clinical Laboratories. For more information regarding Private HLA Testing or to order a test kit, please visit BoneMarrowTest.com.

*By clicking the link above you will be redirected to BoneMarrowTest.com.

Antibody Testing | HLA Antibody Testing | Kashi Clinical Laboratories

Kashi Labs has partnered with ThermoFisher Scientific to bring MMDx® to our patients and providers.

To place an order or find more information regarding MMDx® for Molecular Biopsy Assessment, sample reports, and free specimen collection kit orders, please click the order button.

*By clicking the link above you'll be redirected to the ThermoFisher Scientific website.