Cardiac Health

Genetic Testing | Cardiac Health

Ideal candidates are patients with the following symptoms or conditions:

Treatment-resistant hypertension

Poor control over cholesterol levels

Personal history of angina, DVT, PE, CHF, MI or CVA

Introduction of new statin medications

Family history of cardiovascular disease

Stroke or heart disease in the young

Idiopathic cardiovascular disease

The Kashi Cardiac Health Panel gives insight into how a patient’s genetic predisposition to cardiac problems can help healthcare providers optimize diagnosis and treatment.

Cardiovascular disease is a leading contributor to morbidity and mortality, with over 17 million deaths occurring annually worldwide. Risk increases in adults over the age of 60, and in part is attributable to inherited genetic makeup.

Cardiovascular disease – which includes coronary heart disease, cerebrovascular disease, peripheral artery disease, and atherosclerosis – is heavily influenced by factors such as insulin resistance, hypertension, dyslipidemia, inflammation, and coagulation properties. Many of these factors can be mitigated by lifestyle changes including smoking cessation, increasing aerobic exercise, and eating a well-balanced diet, which can reduce the risk of catastrophic events such as myocardial infarction, or ischemic and hemorrhagic stroke. However, in some cases, particularly where family history of cardiovascular disease is prevalent, medications or more targeted lifestyle interventions are needed to better manage health outcomes.

ApoE 4 does not guarantee that someone will develop Alzheimer’s. After learning about an individual’s genetic makeup, we can recommend steps to take to reduce your risk of developing the disease.

Genetic Markers

Test Categories

Health Effects

ApoE

Impacts management of cholesterol levels and risk of heart attack, stroke, hypertension, and coronary disease

Factor II (Prothrombin)

Affects the body’s ability to form blood clots which is tied to the risk of many cardiovascular-related health outcomes

Factor V

Enhances body’s coagulability which leads to thromboembolisms

MTHFR

Contributes to increased levels of homocysteine, a known risk factor for heart disease, atherosclerosis, and peripheral neuropathy

9p21

Associated with cellular growth and proliferation in relation to atherosclerosis, arterial stiffness and coronary artery disease

eNOS/NOS3

Influences nitric oxide levels leading to risk of endothelial dysfunction, and many subsequent cardiovascular effects

SLCO1B1*5

Modulates the body’s ability to metabolize statin medications, which are commonly prescribed to improve cholesterol

AGT

Key to maintaining blood pressure, patients who carry this mutation may be at an increased risk of developing hypertension

Cardiac Health

Ideal candidates are patients with the following symptoms or conditions:

Genetic Testing

Genetic Markers

Test Categories

Health Effects

For Cardiac Pharmacogenetics, these SNPs are ordered as part of our PGx Comprehensive panel: CYP2D6, CYP2C19, CYP2C9, CYP3A4, CYP3A5, VKORC1

Contact Information

Laboratory Hours

Sample Collection

At-Home Tests

Sample Collection

Kashi Laboratories works directly with providers to make ordering tests as easy as possible.

Kashi Laboratories works directly with providers to make ordering tests as easy as possible.

What can we help you find?

Place a one-time order for genetic testing at order.kashilab.com.

Kashi Laboratories works directly with providers to make ordering tests as easy as possible.

Ordering a kit is easy! To purchase a Private Testing Kit, please visit the link below and follow the steps provided.

Kashi Labs has partnered with ThermoFisher Scientific to bring MMDx® to our patients and providers.