Sjögren’s syndrome is a late onset chronic autoimmune disease which affects the exocrine glands, mainly the salivary and lacrimal glands, resulting in insufficient secretion by those glands.
It is characterized by a progressive lymphoid and plasma cell infiltration of the salivary and tear glands, accompanied by the production of autoantibodies leading to mucosal (dry mouth) and conjunctival (dry eyes) dryness. Sjögren’s may occur alone (primary Sjögren’s) or secondary to other autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. Primary Sjögren’s generally affects females (9/10 patients are female) and has an onset at around age 40. The reasons for the gender bias are unknown though hormones such as prolactin have been implicated.
Multiple genetic loci have been shown to contribute to the risk of developing Sjögren’s. Of these, the HLA class II DR and DQ are the most important. HLA-DQA1*05, DQB1*02, and DRB1*03 alleles are the risk factors for disease. Sjögren’s is diagnosed on the basis of screening questions, eye tests and salivary flow rate tests rather than on genetic testing. Genetic testing in Sjögren’s may be of value in providing insights into the mechanism of the disease, thereby potentially suggesting strategies for prevention and treatment.
To request environmental testing at Kashi Labs, please visit the Order Now page and contact us to get started.
To request toxicology testing at Kashi Labs, please visit the Order Now page and contact us to get started.
If you are an existing provider, please sign in to place an order through the online portal. If you are new to Kashi and would like to create an account, please contact us.
Place a one-time order by contacting us through the form at the link below, or get started by logging in to your online portal.
BoneMarrowTest.com is a service of Kashi Clinical Laboratories. For more information regarding Private HLA Testing or to order a test kit, please visit BoneMarrowTest.com.
*By clicking the link above you will be redirected to BoneMarrowTest.com.
To place an order or find more information regarding MMDx® for Molecular Biopsy Assessment, sample reports, and free specimen collection kit orders, please click the order button.
*By clicking the link above you'll be redirected to the ThermoFisher Scientific website.